Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.68 |
| ▸ | JAK3 | P52333 | 12/20 | 0.62 |
| ▸ | JAK1 | P23458 | 5/20 | 0.62 |
| ▸ | TYK2 | P29597 | 3/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377157 | 0.91 | JAK2 (0.74) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4378731 | 0.83 | JAK2 (0.81) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4380259 | 0.83 | JAK2 (0.70) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL28254694 | 0.82 | JAK2 (1.00) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4383114 | 0.82 | JAK2 (0.72) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4393244 | 0.82 | JAK2 (0.78) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4378486 | 0.81 | JAK2 (0.82) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL2865873 | 0.81 | JAK2 (0.82) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4584236 | 0.81 | JAK2 (0.67) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL4387681 | 0.81 | JAK2 (0.77) | JAK2JAK3JAK1TYK2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |