Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.58 |
| ▸ | JAK3 | P52333 | 12/20 | 0.58 |
| ▸ | CDK2 | P24941 | 4/20 | 0.57 |
| ▸ | JAK1 | P23458 | 6/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | OPA1 | O60313 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | STK16 | O75716 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566128 | 0.92 | JAK2 (0.61) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4380467 | 0.87 | JAK2 (0.77) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4377373 | 0.86 | JAK2 (0.58) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4383485 | 0.85 | JAK2 (0.57) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4383482 | 0.85 | JAK2 (0.78) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4391521 | 0.85 | JAK2 (0.78) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4378864 | 0.84 | JAK2 (0.64) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL4379816 | 0.84 | CDK2 (0.51) | JAK2JAK3CDK2CDK9AURKA | |
| SCHEMBL4384366 | 0.83 | JAK2 (0.60) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL4381964 | 0.83 | JAK2 (0.64) | JAK2JAK3CDK2JAK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |