Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 16/20 | 0.65 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12042835 | 1.00 | OSBP (0.65) | OSBPOSBP2PPARGPPARAMAPT | |
| SCHEMBL2071814 | 1.00 | OSBP (0.65) | OSBPOSBP2PPARGPPARAMAPT | |
| SCHEMBL12042778 | 0.95 | OSBP (0.70) | OSBPOSBP2PPARGPPARAMAPT | |
| SCHEMBL12845471 | 0.94 | OSBP (0.69) | OSBPOSBP2PPARGPPARAMAPT | |
| SCHEMBL2073637 | 0.91 | OSBP (0.80) | OSBPOSBP2PPARGPPARA | |
| SCHEMBL2073634 | 0.91 | OSBP (0.80) | OSBPOSBP2PPARGPPARA | |
| SCHEMBL12783001 | 0.89 | OSBP (0.76) | OSBPOSBP2PPARGPPARA | |
| SCHEMBL2071812 | 0.88 | OSBP (0.64) | OSBPOSBP2MAPT | |
| 3-Deoxyschweinfurthin B SCHEMBL10043035 | 0.85 | OSBP (0.86) | OSBPOSBP2PPARGPPARA | |
| SCHEMBL2073578 | 0.84 | OSBP (0.72) | OSBPOSBP2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732915-B1 | SCHWEINFURTHIN ANALOGUES | UNIV IOWA RES FOUND (US) | 2016-01-06 | — | — | EP | disclosed |
| US-20110319481-A1 | SCHWEINFURTHIN ANALOGUES | Government of the United States of America, National Institute of Health (US) | 2011-12-29 | — | — | US | disclosed |
| US-7358377-B2 | such as: 3-Deoxyschweinfurthin B; tested and were found to have anti-cancer by NCI 60-cell line anticancer assay; e.g. breast cancer or a cancer of the CNS or renal system | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2008-04-15 | — | — | US | disclosed |
| US-20080015232-A1 | SCHWEINFURTHIN ANALOGUES | US GOVERNMENT - SECRETARY FOR THE ARMY | 2008-01-17 | — | — | US | disclosed |
| EP-1732915-A2 | SCHWEINFURTHIN ANALOGUES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092878-A2 | SCHWEINFURTHIN ANALOGUES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015232-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | OSBP 2083/4885OSBP2 2163/4885PPARG 1653/4885 |
| US-20110319481-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | OSBP 2083/4885OSBP2 2163/4885PPARG 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.