Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.32 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.32 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152323 | 0.76 | GSK3A (0.46) | GSK3AGSK3B | |
| SCHEMBL11698307 | 0.76 | GSK3A (0.46) | GSK3AGSK3B | |
| SCHEMBL354379 | 0.74 | MIF (0.41) | GSK3AGSK3B | |
| SCHEMBL10887811 | 0.70 | GFER (0.36) | GSK3AGSK3BCYP1A2ALDH1A1AURKA | |
| SCHEMBL19847083 | 0.69 | GSK3A (0.37) | GSK3AGSK3B | |
| SCHEMBL6814814 | 0.69 | MEN1 (0.38) | GSK3AGSK3BCYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL11348051 | 0.67 | — | — | |
| SCHEMBL277815 | 0.66 | — | — | |
| SCHEMBL26675163 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL27827986 | 0.64 | GSK3A (0.56) | GSK3AGSK3BCYP1A2ALDH1A1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311255-A4 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | PICOWER INST MED RES (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1311255-A1 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2003-05-21 | — | — | EP | disclosed |
| US-6492428-B1 | MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF); SUBSTITUTED IMINOQUINONE OR ORTHOQUINONE RING SYSTEMS | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH | 2002-12-10 | — | — | US | disclosed |
| WO-2002007720-A1 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2002-01-31 | — | — | WO | disclosed |