Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 18/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.59 |
| ▸ | CALCA | P06881 | 1/20 | 0.48 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231179 | 0.83 | CALCRL (0.83) | CALCRLCYP3A4 | |
| SCHEMBL13081467 | 0.83 | CALCRL (0.83) | CALCRLCYP3A4 | |
| SCHEMBL3764531 | 0.83 | CALCRL (0.83) | CALCRLCYP3A4 | |
| SCHEMBL3588012 | 0.83 | CALCRL (0.63) | CALCRLCYP3A4CALCA | |
| SCHEMBL3588008 | 0.83 | CALCRL (0.63) | CALCRLCYP3A4CALCA | |
| SCHEMBL30231279 | 0.83 | CALCRL (0.63) | CALCRLCYP3A4CALCA | |
| SCHEMBL14526916 | 0.80 | CALCRL (0.60) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL13081132 | 0.80 | CALCRL (0.58) | CALCRLCYP3A4CALCA | |
| SCHEMBL14526922 | 0.80 | CALCRL (0.64) | CALCRLCYP3A4RAMP1 | |
| SCHEMBL14526919 | 0.79 | CALCRL (0.65) | CALCRLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689493-A4 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1689493-A1 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Pharma Company (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005065779-A1 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |