⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12675735 | 1.00 | — | — | |
| SCHEMBL12085144 | 1.00 | — | — | |
| SCHEMBL12473717 | 1.00 | — | — | |
| SCHEMBL12675725 | 1.00 | — | — | |
| SCHEMBL46095 | 1.00 | — | — | |
| SCHEMBL684418 | 1.00 | — | — | |
| SCHEMBL5586361 | 1.00 | — | — | |
| SCHEMBL5586362 | 1.00 | — | — | |
| Ammonia Solution, Strong SCHEMBL27563464 | 0.95 | — | — | |
| Ammonia Solution, Strong SCHEMBL28088729 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170057928-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GILEAD SCIENCES, INC. | 2017-03-02 | — | — | US | disclosed |
| US-9302120-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-04-05 | — | — | US | disclosed |
| US-9079913-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-07-14 | — | — | US | disclosed |
| US-20140378680-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-12-25 | — | — | US | disclosed |
| US-8877796-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-04 | — | — | US | disclosed |
| US-20140148494-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-05-29 | — | — | US | disclosed |
| US-8680132-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-03-25 | — | — | US | disclosed |
| US-8629141-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-01-14 | — | — | US | disclosed |
| US-20130296303-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-11-07 | — | — | US | disclosed |
| US-8518984-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-08-27 | — | — | US | disclosed |
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-20120078377-A1 | SYSTEMS, DEVICES AND METHODS FOR PROVIDING THERAPY TO AN ANATOMICAL STRUCTURE USING HIGH FREQUENCY PRESSURE WAVES AND/OR CRYOGENIC TEMPERATURES | ENTRIGUE SURGICAL, INC. (US) | 2012-03-29 | — | — | US | disclosed |
| US-20110201694-A1 | Compositions and Methods for Treatment of Disorders of Protein Aggregation | MCLAURIN JOANNE | 2011-08-18 | — | — | US | disclosed |
| WO-2011060049-A2 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-05-19 | — | — | WO | disclosed |
| US-20110022172-A1 | Disposable Medical Device for Engaging with Reusable Medical Instrument and Methods of Use | ENTRIGUE SURGICAL, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20110015734-A1 | Methods for Providing Therapy to an Anatomical Structure | ENTRIGUE SURGICAL, INC. (US) | 2011-01-20 | — | — | US | disclosed |
| US-20110015667-A1 | Systems, Devices and Methods for Providing Therapy to an Anatomical Structure | ENTRIGUE SURGICAL, INC. (US) | 2011-01-20 | — | — | US | disclosed |
| US-20100312338-A1 | SYSTEMS, DEVICES AND METHODS FOR PROVIDING THERAPY TO AN ANATOMICAL STRUCTURE | ENTRIGUE SURGICAL, INC. (US) | 2010-12-09 | — | — | US | disclosed |