Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 8/20 | 0.45 |
| ▸ | NOS1 | P29475 | 7/20 | 0.45 |
| ▸ | NOS3 | P29474 | 5/20 | 0.45 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL25212883 | 1.00 | OTC (0.47) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL4586458 | 1.00 | OTC (0.47) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL3057586 | 0.97 | OTC (0.44) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL27468620 | 0.97 | OTC (0.44) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL28224090 | 0.94 | OTC (0.43) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL27983903 | 0.94 | OTC (0.43) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL6703685 | 0.93 | OTC (0.42) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL1533652 | 0.93 | GSR (0.53) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL17415104 | 0.93 | GSR (0.53) | OTCSLC7A5NOS2NOS1NOS3 | |
| Arginine SCHEMBL1533521 | 0.93 | GSR (0.53) | OTCSLC7A5NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085862-A4 | METHOD OF TREATING AN AUTOIMMUNE DISORDER | BRYAN THOMAS B (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1085862-A1 | METHOD OF TREATING AN AUTOIMMUNE DISORDER | Bryan, Thomas B. (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999065479-A1 | METHOD OF TREATING AN AUTOIMMUNE DISORDER | BRYAN THOMAS B (US) | 1999-12-23 | — | — | WO | claimed |
| EP-3348578-B1 | DOUBLE-TARGET MUTEIN MUR6S4TR OF TRAIL, AND PREPARATION METHOD AND USE THEREOF | CHENGDU HUACHUANG BIOTECHNOLOGY CO LTD (CN) | 2019-10-09 | — | — | EP | disclosed |
| EP-3348578-A1 | DOUBLE-TARGET MUTEIN MUR6S4TR OF TRAIL, AND PREPARATION METHOD AND USE THEREOF | Chengdu Huachuang Biotechnology Co., Ltd (CN) | 2018-07-18 | — | — | EP | disclosed |
| US-20180170993-A1 | Bi-targeted Mutain MuR6S4TR of TRAIL and Preparation Method and Application Thereof | CHENGDU HUACHUANG BIOTECHNOLOGY CO., LTD (CN) | 2018-06-21 | — | — | US | disclosed |
| EP-3145524-A2 | SYNTHESIS OF BETA-ARRESTIN EFFECTORS | Trevena, Inc. (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179349-A2 | SYNTHESIS OF BETA-ARRESTIN EFFECTORS | TREVENA, INC. (US) | 2015-11-26 | — | — | WO | disclosed |
| EP-2938319-A2 | HAIR COLOURING METHOD EMPLOYING A CHROMENE OR CHROMAN DYE, A PARTICULAR ORGANIC COMPOUND, AN OXIDIZING AGENT, AN ALKALINE AGENT AND A METAL SALT | L'OREAL (FR) | 2015-11-04 | — | — | EP | disclosed |
| WO-2014102338-A2 | HAIR COLOURING METHOD EMPLOYING A CHROMENE OR CHROMAN DYE, A PARTICULAR ORGANIC COMPOUND, AN OXIDIZING AGENT, AN ALKALINE AGENT AND A METAL SALT | L'OREAL (FR) | 2014-07-03 | — | — | WO | disclosed |
| CN-103249428-A | Application of calcineurin inhibitor 1 in preparation of drugs for treating diseases related to NF-kB activity increase | MACLEE TECHNOLOGY INC | 2013-08-14 | — | — | CN | disclosed |
| EP-1526179-B9 | Method for producing l-amino acid using bacteria belonging to the genus escherichia | AJINOMOTO KK (JP) | 2007-10-10 | — | — | EP | disclosed |
| EP-1526179-B1 | Method for producing l-amino acid using bacteria belonging to the genus escherichia | AJINOMOTO KK (JP) | 2007-05-02 | — | — | EP | disclosed |
| EP-0274267-B1 | COSMETIC PRODUCT | UNILEVER PLC (GB) | 1992-07-22 | — | — | EP | disclosed |
| EP-0274267-A1 | Cosmetic product | UNILEVER PLC (GB) | 1988-07-13 | — | — | EP | disclosed |