Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.32 |
| ▸ | HTR1B | P28222 | 2/20 | 0.32 |
| ▸ | HTR1F | P30939 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 4/20 | 0.31 |
| ▸ | MTOR | P42345 | 4/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4587855 | 1.00 | TLR8 (0.33) | TLR8TLR7TLR9PIK3CAHTR4 | |
| SCHEMBL4589942 | 0.82 | CHRM4 (0.44) | HTR1DHTR1BHTR1FCHRM1CHRM2 | |
| SCHEMBL4589945 | 0.82 | CHRM4 (0.44) | HTR1DHTR1BHTR1FCHRM1CHRM2 | |
| SCHEMBL604341 | 0.74 | CHRM4 (0.38) | CHRM1CHRM2CHRM4 | |
| SCHEMBL604342 | 0.74 | CHRM4 (0.38) | CHRM1CHRM2CHRM4 | |
| SCHEMBL1158423 | 0.69 | CHRM1 (0.38) | CHRM1CHRM2CHRM4 | |
| SCHEMBL607149 | 0.68 | ABCB1 (0.39) | CHRM1CHRM2CHRM4 | |
| SCHEMBL607150 | 0.68 | ABCB1 (0.39) | CHRM1CHRM2CHRM4 | |
| SCHEMBL14039811 | 0.68 | IRAK4 (0.41) | TLR7PIK3CAMTOR | |
| SCHEMBL608209 | 0.67 | CHRM4 (0.36) | CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119713-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |