Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 6/20 | 0.60 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586591 | 0.88 | CXCR2 (0.69) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL4587453 | 0.88 | CXCR2 (0.72) | CXCR2CX3CR1 | |
| SCHEMBL4586767 | 0.85 | CXCR2 (0.71) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL6566355 | 0.84 | CXCR2 (0.76) | CXCR2CXCR1 | |
| SCHEMBL4593927 | 0.82 | CXCR2 (0.67) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL6563479 | 0.81 | CXCR2 (0.65) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL6563473 | 0.81 | CXCR2 (0.65) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL7500868 | 0.81 | CXCR2 (0.60) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL5456212 | 0.81 | CXCR2 (0.64) | CXCR2CXCR1CX3CR1 | |
| Trifluoroacetic Acid SCHEMBL4594878 | 0.79 | CXCR2 (0.67) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812008-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-10-29 | — | — | EP | claimed |
| EP-1812008-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006043950-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-27 | — | — | WO | claimed |
| WO-2000041685-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-20 | — | — | WO | disclosed |