Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180 | 0.73 | CDC25B (0.39) | CDC25B | |
| SCHEMBL29965655 | 0.73 | CDC25B (0.39) | CDC25B | |
| SCHEMBL7737681 | 0.70 | CDC25B (0.41) | CDC25B | |
| SCHEMBL4020923 | 0.68 | CDC25B (0.36) | CDC25B | |
| Methyl Alcohol SCHEMBL18284553 | 0.68 | CDC25B (0.36) | CDC25B | |
| SCHEMBL4574418 | 0.66 | CDC25B (0.38) | CDC25B | |
| SCHEMBL7010625 | 0.63 | CDC25B (0.35) | CDC25B | |
| SCHEMBL6541014 | 0.56 | — | — | |
| SCHEMBL2975734 | 0.55 | CDC25B (0.48) | CDC25B | |
| SCHEMBL30956636 | 0.54 | CDC25B (0.65) | CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070219220-A1 | Pyrazolopyrimidinethione Derivatives, Salts and Solvates Thereof, Preparation Methods and Use Thereof | THE INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA (CN) | 2007-09-20 | — | — | US | claimed |
| EP-1695976-A1 | PYRAZOLOPYRIMIDINETHIONE DERIVATIVES, SALTS AND SOLVATES THEREOF, PREPARATION METHODS AND USE THEREOF | Institute of Radiation Medicine Academy of Military Medical Sciences of the Pla (CN) | 2006-08-30 | — | — | EP | claimed |
| EP-1395593-A4 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INST SCI & TECH (KR) | 2004-11-10 | — | — | EP | claimed |
| US-20040176371-A1 | Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-09-09 | — | — | US | claimed |
| EP-1395593-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-03-10 | — | — | EP | claimed |
| WO-2002102802-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2002-12-27 | — | — | WO | claimed |
| WO-2017168174-A1 | NEW PHARMACEUTICAL FORMS OF SILDENAFIL | N4 PHARMA UK LIMITED (GB) | 2017-10-05 | — | — | WO | disclosed |
| EP-1695976-A4 | PYRAZOLOPYRIMIDINETHIONE DERIVATIVES, SALTS AND SOLVATES THEREOF, PREPARATION METHODS AND USE THEREOF | INST RADIATION MED AMMS PLA (CN) | 2008-10-08 | — | — | EP | disclosed |
| US-20070219220-A1 | Pyrazolopyrimidinethione Derivatives, Salts and Solvates Thereof, Preparation Methods and Use Thereof | THE INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA (CN) | 2007-09-20 | — | — | US | disclosed |
| US-20070219220-A1 | Pyrazolopyrimidinethione Derivatives, Salts and Solvates Thereof, Preparation Methods and Use Thereof | THE INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA (CN) | 2007-09-20 | — | — | US | disclosed |
| US-20070219220-A1 | Pyrazolopyrimidinethione Derivatives, Salts and Solvates Thereof, Preparation Methods and Use Thereof | THE INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA (CN) | 2007-09-20 | — | — | US | disclosed |
| EP-1695976-A1 | PYRAZOLOPYRIMIDINETHIONE DERIVATIVES, SALTS AND SOLVATES THEREOF, PREPARATION METHODS AND USE THEREOF | Institute of Radiation Medicine Academy of Military Medical Sciences of the Pla (CN) | 2006-08-30 | — | — | EP | disclosed |
| EP-1695976-A1 | PYRAZOLOPYRIMIDINETHIONE DERIVATIVES, SALTS AND SOLVATES THEREOF, PREPARATION METHODS AND USE THEREOF | Institute of Radiation Medicine Academy of Military Medical Sciences of the Pla (CN) | 2006-08-30 | — | — | EP | disclosed |
| US-20040176371-A1 | Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-09-09 | — | — | US | disclosed |
| US-20040176371-A1 | Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-09-09 | — | — | US | disclosed |
| US-20040176371-A1 | Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-09-09 | — | — | US | disclosed |
| EP-1395593-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-03-10 | — | — | EP | disclosed |
| EP-1395593-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002102802-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2002-12-27 | — | — | WO | disclosed |
| WO-2002102802-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219220-A1 | Pyrazolopyrimidinethione Derivatives, Salts and Solvates Thereof, Preparation Methods and Use Thereof | PDE5A, PDE3B, PDE3A | CDC25B 850/4885 |
| US-20040176371-A1 | Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction | PDE3B, PDE3A, PDE5A | CDC25B 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.