Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 12/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 12/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589470 | 1.00 | CHRM4 (0.42) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL605240 | 0.84 | CHRM4 (0.47) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL607812 | 0.84 | CHRM4 (0.47) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL605239 | 0.84 | CHRM4 (0.47) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL4589945 | 0.76 | CHRM4 (0.44) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL4589942 | 0.76 | CHRM4 (0.44) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL4573233 | 0.75 | CHRM4 (0.42) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL4573228 | 0.75 | CHRM4 (0.42) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL4573164 | 0.75 | CHRM4 (0.45) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL4573174 | 0.75 | CHRM4 (0.45) | CHRM4CHRM5CHRM1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119713-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |