Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SOX18 | P35713 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869422 | 0.91 | CYP1A2 (0.54) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL29546077 | 0.91 | CYP1A2 (0.54) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL14299363 | 0.90 | CYP1A2 (0.53) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL4589937 | 0.88 | CYP1A2 (0.47) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL4590193 | 0.84 | CYP1A2 (0.41) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL25753060 | 0.84 | KDM4E (0.49) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL12308438 | 0.84 | KDM4E (0.49) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL25753059 | 0.84 | KDM4E (0.49) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL4223879 | 0.84 | GBA1 (0.48) | CYP1A2KDM4EMAPK1TDP1CYP2A6 | |
| SCHEMBL14814417 | 0.82 | CYP1A2 (0.47) | CYP1A2KDM4EMAPK1TDP1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |