Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 10/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865919 | 0.86 | PDE9A (0.49) | PDE9APDE1C | |
| SCHEMBL4505702 | 0.84 | PDE9A (0.49) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL13865776 | 0.82 | PDE9A (0.58) | PDE9APDE1C | |
| SCHEMBL13865764 | 0.81 | PDE9A (0.56) | PDE9APDE1C | |
| SCHEMBL6897438 | 0.81 | PDE9A (0.60) | PDE9APDE1C | |
| SCHEMBL4510198 | 0.81 | PDE9A (0.56) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL3725138 | 0.81 | PDE9A (0.56) | PDE9APDE1C | |
| SCHEMBL13870398 | 0.80 | PDE9A (0.60) | PDE9APDE1C | |
| SCHEMBL13865753 | 0.80 | PDE9A (0.57) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| Hydrochloric Acid SCHEMBL4511412 | 0.79 | PDE9A (0.59) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008055959-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-05-15 | — | — | WO | disclosed |