Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 19/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132761 | 0.95 | PIK3CB (0.54) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4148037 | 0.89 | PIK3CB (0.47) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4138827 | 0.84 | PIK3CB (0.57) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4129500 | 0.83 | PIK3CB (0.47) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL4524096 | 0.82 | PIK3CB (0.68) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4147920 | 0.81 | PIK3CB (0.58) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4143775 | 0.80 | PIK3CB (0.64) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4126952 | 0.79 | PIK3CB (0.55) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL4126955 | 0.79 | PIK3CB (0.55) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL4590287 | 0.77 | PIK3CB (0.52) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032089-A1 | 4-BENZIMIDAZ0LYL-2-M0RPH0LIN0-6-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |