Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411525 | 1.00 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL15259935 | 1.00 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL14911007 | 1.00 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Hydrochloric Acid SCHEMBL3243980 | 0.99 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Bromide SCHEMBL1410521 | 0.99 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Hydrochloric Acid SCHEMBL1411735 | 0.99 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Oxalic Acid SCHEMBL1411436 | 0.96 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Sulfuric Acid SCHEMBL1411591 | 0.96 | PDE4D (0.42) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Fumaric Acid SCHEMBL1411515 | 0.93 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Fumaric Acid SCHEMBL1411518 | 0.93 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140039001-A1 | NOVEL SALTS OF 6-HETEROCYCLE SUBSTITUTED HEXAHYDROPHENANTHRIDINE DERIVATIVES | TAKEDA GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| EP-2589599-A1 | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | Takeda GmbH (DE) | 2013-05-08 | — | — | EP | disclosed |
| US-20080194587-A1 | phosphodiesterase inhibitor; drug for respiratory system disorders | NYCOMED GMBH (DE) | 2008-08-14 | — | — | US | disclosed |