Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 11/20 | 0.65 |
| ▸ | PRKAA2 | P54646 | 9/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.65 |
| ▸ | EGFR | P00533 | 4/20 | 0.63 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.55 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115430 | 1.00 | KDR (0.65) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL13755222 | 0.92 | KDR (0.59) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL31672547 | 0.92 | KDR (0.59) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL2115509 | 0.92 | KDR (0.59) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL13755210 | 0.89 | KDR (0.69) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL2118747 | 0.89 | KDR (0.69) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL31672404 | 0.88 | FLT3 (0.66) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL2116210 | 0.88 | FLT3 (0.66) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL13755212 | 0.88 | FLT3 (0.66) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL13755253 | 0.86 | KDR (0.82) | KDRPRKAA1PRKAA2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246046-A1 | AGENT FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | Kyoto University (JP) | 2017-11-22 | — | — | EP | disclosed |
| EP-1536783-B1 | SOLID FORMULATIONS COMPRISING AN INDOLINONE COMPOUND | PFIZER ITALIA SRL (IT) | 2008-08-06 | — | — | EP | disclosed |
| US-7320996-B2 | Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer | SUGEN, INC (US) | 2008-01-22 | — | — | US | disclosed |
| US-6573293-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. | 2003-06-03 | — | — | US | disclosed |