Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.37 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | ADGRF1 | Q5T601 | 1/20 | 0.36 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RNF4 | P78317 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592610 | 0.94 | C5AR1 (0.33) | C5AR1BCL2A1GPR183ADGRF1GPR65 | |
| SCHEMBL4592145 | 0.93 | BCL2A1 (0.41) | C5AR1BCL2A1GPR183ADGRF1GPR65 | |
| SCHEMBL4592440 | 0.92 | BCL2A1 (0.40) | C5AR1BCL2A1GPR183ADGRF1GPR65 | |
| SCHEMBL4592138 | 0.91 | CNR2 (0.34) | TP53MAPTCYP3A4POLBTHRB | |
| SCHEMBL4593125 | 0.90 | BCL2A1 (0.43) | BCL2A1SMN1; SMN2TP53MAPTPOLB | |
| SCHEMBL4592219 | 0.89 | MAPT (0.37) | C5AR1GPR183ADGRF1GPR65SMN1; SMN2 | |
| SCHEMBL5050220 | 0.87 | BCL2A1 (0.43) | C5AR1BCL2A1GPR183ADGRF1GPR65 | |
| SCHEMBL4591412 | 0.85 | GCGR (0.42) | C5AR1CYP3A4ALDH1A1NPBWR1PDK1 | |
| SCHEMBL4591755 | 0.85 | KDM4E (0.33) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL4592510 | 0.85 | CYP3A4 (0.39) | BCL2A1SMN1; SMN2TP53MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885691-A1 | C5A RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2008-02-13 | — | — | EP | claimed |
| WO-2006128670-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-12-07 | — | — | WO | claimed |