Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30423052 | 0.89 | HTT (0.67) | HTTFGFR1CYP17A1 | |
| SCHEMBL27241688 | 0.83 | HTT (0.65) | HTTFGFR1 | |
| SCHEMBL29949277 | 0.81 | HTT (0.57) | HTTFGFR1CYP17A1 | |
| SCHEMBL28848729 | 0.81 | FGFR1 (0.68) | HTTFGFR1 | |
| SCHEMBL22554097 | 0.81 | HTT (0.57) | HTTFGFR1CYP17A1 | |
| SCHEMBL30366915 | 0.81 | HTT (0.57) | HTTFGFR1CYP17A1 | |
| SCHEMBL29949104 | 0.81 | FGFR1 (0.68) | HTTFGFR1 | |
| SCHEMBL28848737 | 0.81 | HTT (0.57) | HTTFGFR1CYP17A1 | |
| SCHEMBL29898319 | 0.81 | FGFR1 (0.67) | HTTFGFR1 | |
| SCHEMBL27728245 | 0.81 | FGFR1 (0.67) | HTTFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |