Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 7/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377784 | 0.86 | JAK2 (0.65) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4378205 | 0.85 | JAK2 (0.64) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL8230904 | 0.78 | JAK2 (0.56) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4383566 | 0.78 | JAK2 (0.77) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4376799 | 0.77 | JAK2 (0.68) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4383788 | 0.77 | JAK2 (0.59) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4382690 | 0.76 | JAK2 (0.58) | JAK2EGFRJAK3 | |
| SCHEMBL4383808 | 0.76 | JAK2 (0.64) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4376881 | 0.76 | JAK2 (0.75) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4379074 | 0.75 | JAK2 (0.61) | JAK2HDAC1HDAC6JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |