Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 16/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3447616 | 1.00 | ACKR3 (0.45) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL4592835 | 0.90 | F10 (0.53) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL3447783 | 0.90 | F10 (0.53) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL3447111 | 0.87 | ACKR3 (0.48) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL3449326 | 0.78 | ACKR3 (0.65) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL3449327 | 0.78 | ACKR3 (0.65) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL20615620 | 0.78 | KDM4E (0.64) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL4592617 | 0.77 | ACKR3 (0.47) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL3449273 | 0.77 | ACKR3 (0.47) | ACKR3F10KDM4EPKMNAMPT | |
| SCHEMBL3449274 | 0.77 | ACKR3 (0.47) | ACKR3F10KDM4EPKMNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877404-A2 | NOVEL CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |