Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220577 | 1.00 | NR1H2 (0.43) | NR1H2BRD4EPHX1STSDDB1 | |
| SCHEMBL29099146 | 0.81 | NR1H2 (0.42) | NR1H2BRD4EPHX1STSDDB1 | |
| SCHEMBL15084775 | 0.81 | NR1H2 (0.45) | NR1H2BRD4EPHX1STSNAMPT | |
| Lithium Ion SCHEMBL21063823 | 0.80 | NR1H2 (0.43) | NR1H2BRD4EPHX1STSNAMPT | |
| SCHEMBL15174329 | 0.79 | NR1H2 (0.46) | NR1H2BRD4EPHX1STSNAMPT | |
| SCHEMBL29161097 | 0.79 | NR1H2 (0.46) | NR1H2BRD4EPHX1STSNAMPT | |
| SCHEMBL18834717 | 0.77 | NR1H2 (0.48) | NR1H2EPHX1DDB1CRBNNAMPT | |
| SCHEMBL221548 | 0.75 | BRD4 (0.57) | NR1H2BRD4STSNAMPTLYPLA1 | |
| SCHEMBL30954929 | 0.75 | BRD4 (0.51) | BRD4EPHX1STSCA12CA1 | |
| SCHEMBL29107918 | 0.75 | BRD4 (0.51) | BRD4EPHX1STSCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888567-A1 | HETEROARYL-CARBOXYLIC ACID (SULFAMOYL ALKYL) AMIDE - DERIVATIVES AS FACTOR XA INHIBITORS | Sanofi-Aventis (FR) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122661-A1 | HETEROARYL-CARBOXYLIC ACID (SULFAMOYL ALKYL) AMIDE - DERIVATIVES AS FACTOR XA INHIBITORS | SANOFI-AVENTIS (DE) | 2006-11-23 | — | — | WO | disclosed |