⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592508 | 0.90 | — | — | |
| SCHEMBL7536082 | 0.88 | SLC1A3 (0.46) | — | |
| SCHEMBL3889697 | 0.80 | SLC1A3 (0.38) | — | |
| SCHEMBL18883522 | 0.78 | SLC1A3 (0.39) | — | |
| SCHEMBL13452 | 0.78 | — | — | |
| SCHEMBL18883524 | 0.78 | SLC1A3 (0.39) | — | |
| SCHEMBL12541302 | 0.78 | SLC1A3 (0.39) | — | |
| SCHEMBL1607385 | 0.75 | — | — | |
| SCHEMBL1607391 | 0.75 | — | — | |
| SCHEMBL1608341 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103500-B1 | PHENETHYL-1-ALPHA-PHENYL-PIPERIDINE-3-PROPANE-NITRILE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL USE | SYNTHELABO (FR) | 1988-01-13 | — | — | EP | claimed |
| EP-0103500-A2 | Phenethyl-1-alpha-phenyl-piperidine-3-propane-nitrile derivatives, their preparation and therapeutical use | SYNTHELABO (FR) | 1984-03-21 | — | — | EP | claimed |
| CN-117980310-A | Alkylene derivatives as KRAS inhibitors | 尼坎治疗公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-2670734-A1 | NOVEL ETHER LINKED COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE | UNIVERSITY OF NOTTINGHAM (GB) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104659-A1 | NOVEL ETHER LINKED COMPOUNDS AND IMPROVED TREATMENTS FOR CARDIAC AND CARDIOVASCULAR DISEASE | UNIVERSITY OF NOTTINGHAM (GB) | 2012-08-09 | — | — | WO | disclosed |
| EP-1934215-A1 | ISOTOPICALLY SUBSTITUTED IMIDAZOPYRIDINE DERIVATIVES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | Nycomed GmbH (DE) | 2008-06-25 | — | — | EP | disclosed |
| EP-1926714-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | Nycomed GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| US-20080119510-A1 | Substituted Imidazo [4,5-B] Pyridines As Inhibitors Of Gastric Acid Secretion | ALTANA PHARMA AG (DE) | 2008-05-22 | — | — | US | disclosed |
| EP-1910313-A1 | 6-THIOAMIDE SUBSTITUTED BENZIMIDAZOLES | Nycomed GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2008015196-A1 | 5-,7-BIS-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES | NYCOMED GMBH (DE) | 2008-02-07 | — | — | WO | disclosed |
| US-7326718-B2 | 8-Substituted imidazopyridines | ALTANA PHARMA AG (DE) | 2008-02-05 | — | — | US | disclosed |
| US-5242943-A | Administering as beta adrenoceptor blocking agents | Louis, William J. (AU) | 1993-09-07 | — | — | US | disclosed |
| US-5051445-A | Cardiovascular disorders such as antiarrhythmia or cardiotonic agents, adrenergic blocking agents | Louis, William J. (AU) | 1991-09-24 | — | — | US | disclosed |
| EP-0177515-B1 | 3-AMINOPROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Louis, William John (AU) | 1989-05-31 | — | — | EP | disclosed |
| EP-0103500-B1 | PHENETHYL-1-ALPHA-PHENYL-PIPERIDINE-3-PROPANE-NITRILE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL USE | SYNTHELABO (FR) | 1988-01-13 | — | — | EP | disclosed |
| EP-0177515-A4 | 3-AMINOPROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | SANDOZ LTD (CH) | 1986-09-23 | — | — | EP | disclosed |
| EP-0177515-A1 | 3-AMINOPROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | SANDOZ LTD (CH) | 1986-04-16 | — | — | EP | disclosed |
| WO-1985004403-A1 | 3-AMINOPROPYLOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANDOZ LTD. (CH) | 1985-10-10 | — | — | WO | disclosed |
| US-4481207-A | CALCIUM ANTAGONISTS, HYPOTENSIVES | SYNTHELABO (FR) | 1984-11-06 | — | — | US | disclosed |
| EP-0103500-A2 | Phenethyl-1-alpha-phenyl-piperidine-3-propane-nitrile derivatives, their preparation and therapeutical use | SYNTHELABO (FR) | 1984-03-21 | — | — | EP | disclosed |