Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.53 |
| ▸ | CDK7 | P50613 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 14/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585264 | 0.86 | CHEK1 (0.51) | CHEK1CDK7KDR | |
| SCHEMBL4586194 | 0.85 | FLT3 (0.50) | CHEK1CDK7KDRSYK | |
| SCHEMBL4586120 | 0.79 | KDR (0.60) | CHEK1KDR | |
| SCHEMBL13524965 | 0.75 | KDR (0.53) | CHEK1CDK7KDRSYK | |
| SCHEMBL14240501 | 0.71 | CHEK1 (0.54) | CHEK1CDK7KDR | |
| SCHEMBL14239634 | 0.71 | FLT3 (0.52) | CHEK1CDK7KDR | |
| SCHEMBL5049638 | 0.70 | FLT3 (0.44) | SYK | |
| SCHEMBL27747831 | 0.70 | SYK (0.40) | CDK7KDRSYK | |
| Hydrochloric Acid SCHEMBL15641143 | 0.70 | FLT3 (0.54) | CHEK1CDK7KDR | |
| SCHEMBL14239621 | 0.70 | KDR (0.59) | CHEK1CDK7KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | claimed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | claimed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | claimed |
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |