Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 8/20 | 0.48 |
| ▸ | JAK3 | P52333 | 6/20 | 0.47 |
| ▸ | JAK1 | P23458 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380385 | 0.88 | JAK2 (0.53) | JAK2HDAC1HDAC6SYKJAK3 | |
| SCHEMBL4383588 | 0.84 | JAK2 (0.67) | JAK2HDAC1HDAC6SYKJAK3 | |
| SCHEMBL4390388 | 0.83 | JAK2 (0.55) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4376808 | 0.83 | JAK2 (0.55) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4376796 | 0.83 | JAK2 (0.55) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4375451 | 0.82 | JAK2 (0.54) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4375456 | 0.82 | JAK2 (0.54) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4385564 | 0.82 | JAK2 (0.54) | JAK2HDAC1HDAC6JAK3JAK1 | |
| SCHEMBL4541386 | 0.77 | JAK2 (0.52) | JAK2HDAC1HDAC6SYKJAK3 | |
| SCHEMBL4379942 | 0.75 | JAK2 (0.61) | JAK2HDAC1HDAC6SYKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |