Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521945 | 1.00 | TAAR1 (0.59) | TAAR1ALDH1A1TDP1POLBAMY1A | |
| SCHEMBL5837446 | 0.83 | TAAR1 (0.44) | TAAR1ALDH1A1TDP1GAAKDM4E | |
| SCHEMBL294086 | 0.82 | TAAR1 (0.52) | TAAR1ALDH1A1TDP1POLBAMY1A | |
| SCHEMBL294085 | 0.82 | TAAR1 (0.52) | TAAR1ALDH1A1TDP1POLBAMY1A | |
| SCHEMBL27835934 | 0.80 | CYP3A4 (0.39) | TAAR1CYP3A4 | |
| SCHEMBL22355712 | 0.78 | TAAR1 (0.52) | TAAR1ALDH1A1TDP1POLBAMY1A | |
| SCHEMBL4746752 | 0.77 | CYP2A6 (0.38) | TAAR1ALDH1A1TDP1POLBKDM4E | |
| SCHEMBL170382 | 0.77 | TAAR1 (0.50) | TAAR1ALDH1A1TDP1POLBAMY1A | |
| SCHEMBL30976143 | 0.77 | TAAR1 (0.50) | TAAR1ALDH1A1TDP1POLBAMY1A | |
| SCHEMBL1124970 | 0.77 | TAAR1 (0.50) | TAAR1ALDH1A1TDP1POLBAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081140-B1 | Novel Pyrimidine-2,4,6-trione compounds | DSM IP ASSETS BV (NL) | 2005-06-01 | — | — | EP | claimed |
| EP-1000950-B1 | Novel indanylidene compounds | HOFFMANN LA ROCHE (CH) | 2004-02-25 | — | — | EP | claimed |
| US-6416746-B1 | ULTRAVIOLET RAY AND LIGHT SCREENING MATERIAL GRAFTED TO SILANE, OLIGOSILOXANE, OR POLYSILOXANE WITH IMPROVED SOLUBILITY AND LITTLE PENETRATION; FOR USE IN COSMETICS | ROCHE VITAMINS INC. | 2002-07-09 | — | — | US | claimed |
| EP-1081140-A2 | Novel Pyrimidine-2,4,6-trione compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-07 | — | — | EP | claimed |
| EP-1000950-A2 | Novel indanylidene compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-17 | — | — | EP | claimed |
| JP-1301629-A | — | — | None | — | — | JP | disclosed |
| JP-7017879-A | — | — | None | — | — | JP | disclosed |
| JP-7309789-A | — | — | None | — | — | JP | disclosed |
| EP-3019142-B1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND / OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP ASSETS BV (NL) | 2017-10-04 | — | — | EP | disclosed |
| US-20160143831-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP ASSETS B.V. (NL) | 2016-05-26 | — | — | US | disclosed |
| EP-3019142-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP Assets B.V. (NL) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015003987-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP ASSETS B.V. (NL) | 2015-01-15 | — | — | WO | disclosed |
| WO-2003086340-A1 | ORGANOSILICONE DERIVATIVES OF AMINO HYDROXYBENZOPHENONES AND THEIR USE AS UV-A FILTERS IN COSMETIC PREPARATIONS | DSM IP ASSETS B.V. (NL) | 2003-10-23 | — | — | WO | disclosed |
| US-6573269-B1 | Compounds for protecting surface of substrate from ultraviolet light | ROCHE VITAMINS INC. | 2003-06-03 | — | — | US | disclosed |
| US-6416746-B1 | ULTRAVIOLET RAY AND LIGHT SCREENING MATERIAL GRAFTED TO SILANE, OLIGOSILOXANE, OR POLYSILOXANE WITH IMPROVED SOLUBILITY AND LITTLE PENETRATION; FOR USE IN COSMETICS | ROCHE VITAMINS INC. | 2002-07-09 | — | — | US | disclosed |
| EP-1081140-A2 | Novel Pyrimidine-2,4,6-trione compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| EP-1000950-A2 | Novel indanylidene compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-17 | — | — | EP | disclosed |
| JP-H07309789-A | PRODUCTION OF 2,6-DIMETHYLNAPHTHALENE | MITSUBISHI CHEM CORP | 1995-11-28 | — | — | JP | disclosed |
| JP-H0717879-A | PRODUCTION OF 2,6-DIMETHYLNAPHTHALENE | MITSUBISHI CHEM CORP | 1995-01-20 | — | — | JP | disclosed |
| JP-H01301629-A | PRODUCTION OF NAPHTHALENES | MITSUI PETROCHEM IND LTD | 1989-12-05 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160143831-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | RAD50, SERPINB10, XRCC5 | TAAR1 3396/4885ALDH1A1 1327/4885TDP1 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.