Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 17/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547999 | 0.81 | HRH4 (0.80) | HRH4ALDH1A1LMNAKMT2AGPR55 | |
| SCHEMBL603184 | 0.81 | HRH4 (0.83) | HRH4ALDH1A1LMNAKMT2AGPR55 | |
| SCHEMBL605566 | 0.80 | HRH4 (1.00) | HRH4TSHRHSD17B10KDM4EMAPT | |
| SCHEMBL603722 | 0.80 | HRH4 (1.00) | HRH4TSHRHSD17B10KDM4EMAPT | |
| SCHEMBL4594647 | 0.80 | HRH4 (1.00) | HRH4TSHRHSD17B10KDM4EMAPT | |
| SCHEMBL603938 | 0.78 | HRH4 (0.75) | HRH4 | |
| SCHEMBL604737 | 0.78 | HRH4 (0.84) | HRH4ALDH1A1LMNAKMT2AGPR55 | |
| SCHEMBL606841 | 0.78 | HRH4 (1.00) | HRH4 | |
| SCHEMBL4739169 | 0.78 | HRH4 (0.69) | HRH4ALDH1A1LMNAKMT2AGPR55 | |
| SCHEMBL603973 | 0.78 | HRH4 (0.69) | HRH4ALDH1A1LMNAKMT2AGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945646-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Cellzome (UK) Ltd. (GB) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007039467-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME (UK) LTD. (GB) | 2007-04-12 | — | — | WO | disclosed |