Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 8/20 | 0.55 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 7/20 | 0.51 |
| ▸ | SRC | P12931 | 7/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126931 | 0.89 | AR (0.55) | EGFRFYNSRCERBB2JAK3 | |
| SCHEMBL24151660 | 0.86 | JAK3 (0.58) | IMPDH2FYNSRCJAK3VCP | |
| SCHEMBL30190528 | 0.86 | JAK3 (0.58) | IMPDH2FYNSRCJAK3VCP | |
| SCHEMBL24150335 | 0.84 | JAK3 (0.47) | IMPDH2EGFRBAZ1AFYNSRC | |
| SCHEMBL30190618 | 0.81 | MAP4K4 (0.44) | IMPDH2FYNSRCJAK3VCP | |
| SCHEMBL24150841 | 0.81 | MAP4K4 (0.44) | IMPDH2FYNSRCJAK3VCP | |
| SCHEMBL24150229 | 0.78 | PLCG1 (0.44) | IMPDH2EGFRBAZ1AFYNSRC | |
| SCHEMBL24151659 | 0.77 | FGFR4 (0.46) | IMPDH2FYNSRCNOTUMJAK3 | |
| SCHEMBL31036070 | 0.75 | NOTUM (0.61) | IMPDH2EGFRBAZ1ANOTUMPRMT3 | |
| SCHEMBL28145788 | 0.74 | EGFR (0.63) | IMPDH2EGFRBAZ1ANOTUMPRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016010961-A1 | ENZYME OCCUPANCY ASSAY | ABBVIE INC. (US) | 2016-01-21 | — | — | WO | disclosed |
| EP-1579186-A4 | IDENTIFICATION OF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2008-10-08 | — | — | EP | disclosed |
| US-7202033-B2 | Identification of kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1579186-A2 | IDENTIFICATION OF KINASE INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20030232391-A1 | Identification of kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. | 2003-12-18 | — | — | US | disclosed |
| WO-2003081210-A2 | IDENTIFICATION OF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2003-10-02 | — | — | WO | disclosed |