Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.77 |
| ▸ | JAK3 | P52333 | 13/20 | 0.77 |
| ▸ | JAK1 | P23458 | 5/20 | 0.77 |
| ▸ | TYK2 | P29597 | 3/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.77 |
| ▸ | FLT3 | P36888 | 2/20 | 0.77 |
| ▸ | IKBKB | O14920 | 2/20 | 0.77 |
| ▸ | KIT | P10721 | 1/20 | 0.77 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.77 |
| ▸ | FLT1 | P17948 | 1/20 | 0.77 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.77 |
| ▸ | FLT4 | P35916 | 1/20 | 0.77 |
| ▸ | KDR | P35968 | 1/20 | 0.77 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.77 |
| ▸ | PLK4 | O00444 | 1/20 | 0.77 |
| ▸ | CIT | O14578 | 1/20 | 0.77 |
| ▸ | GAK | O14976 | 1/20 | 0.77 |
| ▸ | BUB1 | O43683 | 1/20 | 0.77 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593971 | 0.94 | JAK2 (0.70) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL4378034 | 0.89 | JAK2 (0.95) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL4382090 | 0.89 | JAK2 (0.84) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL4378206 | 0.89 | JAK2 (0.84) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL4379072 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL30925304 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL4380116 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL29366461 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| Xl-019 SCHEMBL4382715 | 0.88 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL4378445 | 0.87 | JAK2 (0.95) | JAK2JAK3JAK1TYK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |