Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585514 | 0.85 | KDR (0.46) | KDRCHEK1CHEK2 | |
| SCHEMBL4594057 | 0.84 | KDR (0.49) | KDR | |
| SCHEMBL4586348 | 0.80 | KDR (0.47) | KDR | |
| SCHEMBL4594715 | 0.77 | KDR (0.43) | KDR | |
| SCHEMBL4593852 | 0.76 | KDR (0.43) | KDRCHEK1 | |
| SCHEMBL7003815 | 0.75 | KDR (0.55) | KDR | |
| SCHEMBL6178725 | 0.75 | KDR (0.64) | KDRCHEK1CHEK2 | |
| SCHEMBL4585902 | 0.74 | KDR (0.45) | KDR | |
| SCHEMBL4586129 | 0.73 | KDR (0.41) | KDR | |
| SCHEMBL4587556 | 0.73 | KDR (0.59) | KDRCHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |