Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16570813 | 0.92 | KDM4E (1.00) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| SCHEMBL429276 | 0.92 | KDM4E (1.00) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| Water SCHEMBL7425166 | 0.90 | KDM4E (0.95) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2674609 | 0.90 | KDM4E (0.95) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16571085 | 0.90 | KDM4E (0.95) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| SCHEMBL11205570 | 0.90 | KDM4E (1.00) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8859868 | 0.90 | KDM4E (0.95) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| SCHEMBL13833218 | 0.90 | KDM4E (1.00) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| SCHEMBL17996821 | 0.86 | KDM4E (0.81) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 | |
| SCHEMBL15867648 | 0.81 | KDM4E (0.81) | KDM4EHSD17B10TSHRALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937674-A1 | ISOXAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042420-A1 | ISOXAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |