Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 0.56 |
| ▸ | FYN | P06241 | 4/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594541 | 0.88 | FYN (0.69) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4595298 | 0.88 | PIM1 (0.60) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4595300 | 0.86 | FYN (0.51) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4344837 | 0.83 | PIM1 (0.55) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4594999 | 0.82 | PIM1 (0.58) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4327456 | 0.81 | RET (0.68) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4332422 | 0.81 | PIM1 (0.70) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4328498 | 0.81 | FYN (0.76) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4595396 | 0.79 | FYN (0.64) | PIM1FYNPIM2PIK3CGRET | |
| SCHEMBL4335564 | 0.79 | FYN (0.60) | PIM1FYNPIM2PIK3CGRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | disclosed |