Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ARG1 | P05089 | 1/20 | 0.44 |
| ▸ | ARG2 | P78540 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16295744 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ASLC6A2TAAR1CYP1A2 | |
| SCHEMBL15743149 | 0.85 | BLM (0.64) | SMN1; SMN2HIF1ABLMCYP1A2RECQL | |
| SCHEMBL27889856 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1ASLC6A2TAAR1BLM | |
| SCHEMBL11067231 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1ASLC6A2TAAR1BLM | |
| SCHEMBL11067201 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1ASLC6A2TAAR1BLM | |
| SCHEMBL1081531 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2HIF1ASLC6A2TAAR1BLM | |
| SCHEMBL2130041 | 0.78 | TSHR (0.49) | SMN1; SMN2CYP1A2RECQLTSHRALDH1A1 | |
| SCHEMBL934104 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1ASLC6A2TAAR1PPARG | |
| SCHEMBL2678813 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1ASLC6A2TAAR1PPARG | |
| SCHEMBL25435256 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2HIF1ASLC6A2TAAR1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | disclosed |
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | SMN1; SMN2 3299/4885HIF1A 3343/4885SLC6A2 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.