Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595825 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL4596454 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL4596458 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL4595727 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL5061895 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL4595722 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL4595714 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL8285438 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL21524886 | 0.84 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HRH1MLNR | |
| SCHEMBL6540781 | 0.83 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HRH1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | disclosed |
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | SLC6A2 4822/4885SLC6A4 4637/4885SLC6A3 4780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.