Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396542 | 0.90 | MEN1 (0.50) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2395427 | 0.82 | MEN1 (0.46) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2395156 | 0.81 | CDK2 (0.59) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2396147 | 0.80 | MEN1 (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2395910 | 0.78 | MEN1 (0.60) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL6274171 | 0.77 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2396859 | 0.74 | MEN1 (0.50) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2398695 | 0.73 | MEN1 (0.76) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2395898 | 0.73 | MEN1 (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 | |
| SCHEMBL2395892 | 0.73 | MEN1 (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| EP-1608647-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | Novartis AG (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078754-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2004-09-16 | — | — | WO | disclosed |