Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692666 | 1.00 | KDM4E (0.32) | KDM4EPKMNAALAD2 | |
| SCHEMBL5010290 | 0.81 | NAALAD2 (0.32) | NAALAD2 | |
| SCHEMBL1583855 | 0.78 | KDM4E (0.38) | KDM4E | |
| SCHEMBL25661006 | 0.77 | — | — | |
| SCHEMBL1028106 | 0.76 | NAALAD2 (0.32) | KDM4ENAALAD2 | |
| SCHEMBL19332407 | 0.75 | HMGCR (0.36) | KDM4E | |
| SCHEMBL4577529 | 0.74 | KMT2A (0.38) | KDM4EPKMNAALAD2 | |
| SCHEMBL2490315 | 0.74 | — | — | |
| SCHEMBL5194246 | 0.73 | PIK3CD (0.34) | — | |
| SCHEMBL3910915 | 0.73 | KDM4C (0.37) | NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |