Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094061 | 1.00 | HRH3 (0.54) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL4094053 | 1.00 | HRH3 (0.54) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL4094055 | 1.00 | HRH3 (0.54) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL4094182 | 0.96 | HRH3 (0.53) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL4094185 | 0.96 | HRH3 (0.53) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL4094191 | 0.96 | HRH3 (0.53) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL4597538 | 0.96 | HRH3 (0.53) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL12062515 | 0.87 | HRH3 (0.68) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL12062465 | 0.84 | HRH3 (0.67) | HRH3MAOBHRH2HRH1KDM4E | |
| SCHEMBL17266474 | 0.82 | KDM4E (0.45) | HRH3MAOBHRH2HRH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874746-A2 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | BIOPROJET (FR) | 2008-01-09 | — | — | EP | claimed |
| WO-2006117609-A2 | PHENOXYPROPYLPIPERIDINES AND -PYRROLIDINES AND THEIR USE AS HISTAMINE H3 -RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-11-09 | — | — | WO | claimed |
| EP-1874746-A2 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | BIOPROJET (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006117609-A2 | PHENOXYPROPYLPIPERIDINES AND -PYRROLIDINES AND THEIR USE AS HISTAMINE H3 -RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-11-09 | — | — | WO | disclosed |