SCHEMBL4596832

SCHEMBL4596832

CC1(C)CCCN(CCCOc2ccc(-c3ccncc3)cc2)C1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.63
HRH3 Q9Y5N1 13/20 0.56
HRH1 P35367 6/20 0.56
HRH2 P25021 5/20 0.56
KCNH2 Q12809 2/20 0.50
LTA4H P09960 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
DRD2 P14416 1/20 0.49
BMPR1B O00238 1/20 0.48
PRKAB2 O43741 1/20 0.48
LCK P06239 1/20 0.48
YES1 P07947 1/20 0.48
THRB P10828 1/20 0.48
BMP4 P12644 1/20 0.48
SRC P12931 1/20 0.48
FLT1 P17948 1/20 0.48
EIF2AK2 P19525 1/20 0.48
EPHA2 P29317 1/20 0.48
KDR P35968 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14495446 0.83 MAOB (0.70) MAOBHRH3DRD2
SCHEMBL2280615 0.82 MAOB (0.72) MAOBHRH3DRD2
SCHEMBL12050716 0.82 HRH3 (0.82) HRH3HRH1HRH2KCNH2LTA4H
SCHEMBL2285731 0.78 MAOB (0.56) MAOBHRH3HRH1HRH2KCNH2
Hydrochloric Acid SCHEMBL2290754 0.77 MAOB (0.55) MAOBHRH3HRH1HRH2KCNH2
Hydrochloric Acid SCHEMBL2290759 0.77 MAOB (0.55) MAOBHRH3HRH1HRH2KCNH2
SCHEMBL4596833 0.77 CYP3A4 (0.51) HRH3HRH1HRH2KCNH2LTA4H
SCHEMBL12376852 0.76 HRH3 (0.62) MAOBHRH3HRH1HRH2DRD2
SCHEMBL13437934 0.76 MAOB (0.60) MAOBHRH3HRH1HRH2KCNH2
SCHEMBL5187089 0.76 HRH3 (0.77) MAOBHRH3HRH1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1874746-A2 NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS BIOPROJET (FR) 2008-01-09 EP disclosed
WO-2006117609-A2 PHENOXYPROPYLPIPERIDINES AND -PYRROLIDINES AND THEIR USE AS HISTAMINE H3 -RECEPTOR LIGANDS BIOPROJET (FR) 2006-11-09 WO disclosed