Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 4/20 | 0.64 |
| ▸ | HRH1 | P35367 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094705 | 1.00 | HRH2 (0.64) | HRH2HRH1KDM4EHRH3MAOB | |
| SCHEMBL492475 | 1.00 | HRH2 (0.64) | HRH2HRH1KDM4EHRH3MAOB | |
| SCHEMBL492041 | 1.00 | HRH2 (0.64) | HRH2HRH1KDM4EHRH3MAOB | |
| SCHEMBL492040 | 1.00 | HRH2 (0.64) | HRH2HRH1KDM4EHRH3MAOB | |
| SCHEMBL7390114 | 0.93 | HRH2 (0.66) | HRH2HRH1KDM4EHRH3KMT2A | |
| SCHEMBL5283396 | 0.91 | KDM4E (0.64) | HRH2HRH1KDM4EHRH3SMN1; SMN2 | |
| SCHEMBL12050600 | 0.89 | HRH3 (0.60) | HRH2HRH1KDM4EHRH3MAOB | |
| SCHEMBL12050598 | 0.89 | KDM4E (0.63) | HRH2HRH1KDM4EHRH3MAOB | |
| SCHEMBL4101087 | 0.87 | KDM4E (0.66) | HRH2HRH1KDM4EHRH3MAOB | |
| SCHEMBL4101085 | 0.87 | KDM4E (0.66) | HRH2HRH1KDM4EHRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874746-A2 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | BIOPROJET (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006117609-A2 | PHENOXYPROPYLPIPERIDINES AND -PYRROLIDINES AND THEIR USE AS HISTAMINE H3 -RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-11-09 | — | — | WO | disclosed |