Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.69 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090519 | 0.83 | HRH3 (0.97) | HRH3KCNH2 | |
| SCHEMBL4090678 | 0.82 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4672757 | 0.81 | HRH3 (0.62) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL4094623 | 0.81 | HRH3 (0.66) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL4094626 | 0.81 | HRH3 (0.66) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL736582 | 0.80 | HRH3 (0.62) | HRH3KCNH2 | |
| SCHEMBL1776447 | 0.79 | HRH3 (0.71) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL20652676 | 0.79 | HRH3 (0.67) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL12128607 | 0.79 | HRH3 (0.67) | HRH3MAOBHRH2HRH1 | |
| SCHEMBL1777134 | 0.78 | HRH3 (0.57) | HRH3MAOBHRH2HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874746-A2 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | BIOPROJET (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006117609-A2 | PHENOXYPROPYLPIPERIDINES AND -PYRROLIDINES AND THEIR USE AS HISTAMINE H3 -RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-11-09 | — | — | WO | disclosed |