Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.72 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597844 | 0.97 | APP (0.72) | APPAKR1C3AKR1C2AKR1C1CYP2C19 | |
| SCHEMBL16868072 | 0.84 | APP (0.58) | APPAKR1C3AKR1C2AKR1C1LTB4R | |
| SCHEMBL1373506 | 0.84 | APP (1.00) | APPAKR1C3AKR1C2AKR1C1CYP2C19 | |
| SCHEMBL1203183 | 0.83 | APP (0.61) | APPAKR1C3AKR1C2AKR1C1CYP2C19 | |
| SCHEMBL1202615 | 0.83 | APP (0.58) | APPAKR1C3AKR1C2AKR1C1CYP2C19 | |
| SCHEMBL4597113 | 0.83 | APP (0.60) | APPAKR1C3AKR1C2AKR1C1CYP2C19 | |
| SCHEMBL1201831 | 0.81 | APP (0.57) | APPAKR1C3AKR1C2AKR1C1CYP2C19 | |
| SCHEMBL1203311 | 0.80 | APP (0.54) | APPAKR1C3AKR1C2AKR1C1CYP3A4 | |
| SCHEMBL694972 | 0.77 | APP (0.66) | APPAKR1C3AKR1C2AKR1C1CYP2C19 | |
| SCHEMBL2850290 | 0.76 | APP (0.52) | APPAKR1C3AKR1C2AKR1C1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2008-12-04 | — | — | US | disclosed |
| EP-1773315-B1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2008-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | PSEN2, PSEN1, NAT1 | APP 5/4885AKR1C3 521/4885AKR1C2 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.