Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.51 |
| ▸ | TLR2 | O60603 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23746434 | 0.95 | PRCP (0.56) | PRCPTLR2EPHX1HTR2CHTR2B | |
| SCHEMBL23746435 | 0.95 | PRCP (0.56) | PRCPTLR2EPHX1HTR2CHTR2B | |
| SCHEMBL7268451 | 0.95 | PRCP (0.56) | PRCPTLR2EPHX1HTR2CHTR2B | |
| SCHEMBL6954674 | 0.89 | PRCP (0.50) | PRCPTLR2HTR2CHTR2BDPP7 | |
| SCHEMBL26716600 | 0.84 | PRCP (0.56) | PRCPTLR2HTR2CHTR2BDPP7 | |
| SCHEMBL13306209 | 0.83 | PRCP (0.55) | PRCPTLR2HTR2CHTR2BDPP7 | |
| SCHEMBL13359247 | 0.82 | PRCP (0.61) | PRCPTLR2EPHX1HTR2CHTR2B | |
| SCHEMBL13990631 | 0.82 | PRCP (0.61) | PRCPTLR2EPHX1HTR2CHTR2B | |
| SCHEMBL4710537 | 0.82 | PRCP (0.61) | PRCPTLR2EPHX1HTR2CHTR2B | |
| SCHEMBL27329773 | 0.81 | PRCP (0.56) | PRCPTLR2HTR2CHTR2BDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877400-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | Amgen, Inc (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1802605-A1 | IMIDAZOLE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Amgen, Inc (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006113769-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006044527-A1 | IMIDAZOLE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | AMGEN INC. (US) | 2006-04-27 | — | — | WO | disclosed |