Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | PARP1 | P09874 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2758646 | 0.97 | HRH1 (0.80) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL5060399 | 0.97 | HRH1 (0.80) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL4105413 | 0.97 | HRH1 (0.80) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL5066487 | 0.92 | HRH1 (0.71) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL5056598 | 0.92 | HRH1 (0.71) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL9749941 | 0.92 | HRH1 (0.71) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL9750001 | 0.90 | HRH1 (0.68) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL5061720 | 0.90 | HRH1 (0.68) | HRH1LMNAPARP1KCNH2 | |
| SCHEMBL5061538 | 0.90 | HRH1 (0.68) | HRH1LMNAPARP1KCNH2 | |
| Olopatadine SCHEMBL4669 | 0.88 | HRH1 (1.00) | HRH1LMNAPARP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908758-A1 | Process for the preparation of (Z)-[11-(3-dimethylamino-propyliden)-6,11-dihydro-dibenzo[b,e]oxepin-2-yl]-acetic acid hydrochloride | Urquima S.A. (ES) | 2008-04-09 | — | — | EP | claimed |
| EP-1908758-A1 | Process for the preparation of (Z)-[11-(3-dimethylamino-propyliden)-6,11-dihydro-dibenzo[b,e]oxepin-2-yl]-acetic acid hydrochloride | Urquima S.A. (ES) | 2008-04-09 | — | — | EP | disclosed |