Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 17/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | PLK1 | P53350 | 2/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.56 |
| ▸ | PRKX | P51817 | 1/20 | 0.56 |
| ▸ | NEK4 | P51957 | 1/20 | 0.56 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.56 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596974 | 0.93 | MAPKAPK2 (0.62) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4597283 | 0.93 | MAPKAPK2 (0.62) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4598782 | 0.90 | MAPKAPK2 (0.60) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4598955 | 0.89 | MAPKAPK2 (0.61) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4916606 | 0.89 | MAPKAPK2 (0.61) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4915805 | 0.86 | MAPKAPK2 (0.50) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4915817 | 0.86 | MAPKAPK2 (0.50) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4374212 | 0.83 | MAPKAPK2 (0.80) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4939185 | 0.82 | CXCR2 (0.43) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 | |
| SCHEMBL4598956 | 0.81 | MAPKAPK2 (0.58) | MAPKAPK2MAPK14AURKBPDGFRACSNK1G1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | claimed |
| EP-1910277-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| WO-2007014607-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | claimed |
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| WO-2007014607-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | CHEK1, CHEK2, SIK1 | MAPKAPK2 377/4885MAPK14 1114/4885AURKB 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.