Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | METAP1 | P53582 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453492 | 0.86 | MAPT (0.48) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL12825223 | 0.83 | MEN1 (0.58) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL27631827 | 0.83 | TDP1 (0.63) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6451114 | 0.82 | NPC1 (0.66) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL30503070 | 0.82 | MAPT (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2646693 | 0.82 | MAPT (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL30739547 | 0.82 | PDE7A (0.53) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1013918 | 0.82 | PDE7A (0.53) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6452828 | 0.81 | NPC1 (0.52) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11046684 | 0.80 | MEN1 (0.56) | MAPTMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| EP-1910277-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007014607-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007014607-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | CHEK1, CHEK2, SIK1 | MAPT 3173/4885MEN1 3067/4885KMT2A 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.