Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499604 | 0.69 | KMT2A (0.60) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3672982 | 0.69 | POLB (0.34) | POLB | |
| SCHEMBL8363999 | 0.67 | POLB (0.50) | POLBRAB9ANPC1LMNAMAPK1 | |
| SCHEMBL8363998 | 0.66 | POLB (0.53) | POLBRAB9ANPC1LMNAMAPK1 | |
| Water SCHEMBL27820020 | 0.66 | — | — | |
| SCHEMBL1489407 | 0.63 | GLA (0.35) | POLBLMNAMAPTKMT2A | |
| SCHEMBL14935526 | 0.63 | POLB (0.46) | POLBRAB9ANPC1LMNAMAPK1 | |
| SCHEMBL21371642 | 0.63 | POLB (0.46) | POLBRAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2240888 | 0.63 | POLB (0.33) | POLB | |
| SCHEMBL2964264 | 0.63 | GLA (0.30) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910292-A1 | PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST | Takeda Pharmaceutical Company Limited (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015588-A1 | PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-08 | — | — | WO | disclosed |