Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.65 |
| ▸ | MEN1 | O00255 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600539 | 0.89 | KMT2A (0.63) | PRKCIKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL447449 | 0.86 | NAPRT (0.51) | PRKCIKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1817201 | 0.84 | SMN1; SMN2 (0.55) | PRKCIKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL445818 | 0.83 | EGLN1 (0.62) | RAB9ANPC1EGLN1KDR | |
| Hydrochloric Acid SCHEMBL2105320 | 0.83 | SMN1; SMN2 (0.54) | PRKCIKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4970426 | 0.82 | NPC1 (0.68) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL444553 | 0.82 | TRPV1 (0.60) | KDM4E | |
| SCHEMBL20618438 | 0.81 | EGLN1 (0.61) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL3956492 | 0.81 | EGLN1 (0.50) | PRKCIKMT2AMEN1ALDH1A1NAPRT | |
| SCHEMBL13175094 | 0.80 | PRKCI (0.67) | PRKCIKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102203065-B | Novel phenylamide or pyridylamide derivatives and their use as GPBAR1 agonists | HOFFMANN LA ROCHE | 2014-07-09 | — | — | CN | claimed |
| CN-102203065-B | Novel phenylamide or pyridylamide derivatives and their use as GPBAR1 agonists | HOFFMANN LA ROCHE | 2014-07-09 | — | — | CN | disclosed |
| EP-1910295-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007028456-A1 | SUBSTITUTED PYRIDOCARBOXAMIDES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) | BAYER HEALTHCARE AG (DE) | 2007-03-15 | — | — | WO | disclosed |