Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.84 |
| ▸ | PDE6D | O43924 | 4/20 | 0.84 |
| ▸ | PDE6A | P16499 | 4/20 | 0.84 |
| ▸ | PDE6G | P18545 | 4/20 | 0.84 |
| ▸ | PDE6B | P35913 | 4/20 | 0.84 |
| ▸ | PDE6C | P51160 | 4/20 | 0.84 |
| ▸ | PDE6H | Q13956 | 4/20 | 0.84 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.84 |
| ▸ | ACHE | P22303 | 4/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600804 | 1.00 | PDE5A (0.84) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4601357 | 0.96 | PDE5A (0.80) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4601548 | 0.96 | PDE5A (0.80) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7689505 | 0.88 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7689509 | 0.88 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7689503 | 0.88 | PDE5A (0.91) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7449046 | 0.88 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7430389 | 0.88 | PDE5A (0.91) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7689495 | 0.88 | PDE5A (0.91) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6502559 | 0.87 | PDE5A (0.84) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1914235-A1 | CHIRAL TETRA-HYDRO BETA-CARBOLINE DERIVATIVES AND APPLICATIONS THEREOF AS ANTIPARASITIC COMPOUNDS | Universite de Lille 2 Droit et Santé (FR) | 2008-04-23 | — | — | EP | disclosed |
| EP-1914235-A1 | CHIRAL TETRA-HYDRO BETA-CARBOLINE DERIVATIVES AND APPLICATIONS THEREOF AS ANTIPARASITIC COMPOUNDS | Universite de Lille 2 Droit et Santé (FR) | 2008-04-23 | — | — | EP | disclosed |
| WO-2008044144-A2 | CHIRAL TETRA-HYDRO BETA-CARBOLIC DERIVATIVES AND APPLICATIONS THEREOF AS ANTIPARASITIC COMPOUNDS | UNIVERSITE DE LILLE 2, UNIVERSITÉ DU DROIT ET DE LA SANTÉ (FR) | 2008-04-17 | — | — | WO | disclosed |