Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.81 |
| ▸ | PDE6D | O43924 | 6/20 | 0.72 |
| ▸ | PDE6A | P16499 | 6/20 | 0.72 |
| ▸ | PDE6G | P18545 | 6/20 | 0.72 |
| ▸ | PDE6B | P35913 | 6/20 | 0.72 |
| ▸ | PDE6C | P51160 | 6/20 | 0.72 |
| ▸ | PDE6H | Q13956 | 6/20 | 0.72 |
| ▸ | PDE11A | Q9HCR9 | 8/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | ACHE | P22303 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599779 | 1.00 | PDE5A (0.81) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4600926 | 1.00 | PDE5A (0.81) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4600924 | 1.00 | PDE5A (0.81) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL17390222 | 0.95 | PDE5A (0.86) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL1327318 | 0.92 | PDE5A (0.92) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL1327321 | 0.92 | PDE5A (0.92) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL1327324 | 0.92 | PDE5A (0.92) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL1327741 | 0.90 | PDE5A (0.98) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6782140 | 0.90 | PDE5A (0.98) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6782137 | 0.90 | PDE5A (0.98) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1914235-A1 | CHIRAL TETRA-HYDRO BETA-CARBOLINE DERIVATIVES AND APPLICATIONS THEREOF AS ANTIPARASITIC COMPOUNDS | Universite de Lille 2 Droit et Santé (FR) | 2008-04-23 | — | — | EP | disclosed |