Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27488557 | 1.00 | CHRM4 (0.54) | CHRM4NPC1RAB9AMAPK1CCR5 | |
| SCHEMBL6625512 | 1.00 | CHRM4 (0.54) | CHRM4NPC1RAB9AMAPK1CCR5 | |
| SCHEMBL4601018 | 1.00 | CHRM4 (0.54) | CHRM4NPC1RAB9AMAPK1CCR5 | |
| Hydrochloric Acid SCHEMBL4600885 | 0.99 | CHRM4 (0.53) | CHRM4NPC1RAB9AMAPK1CCR5 | |
| SCHEMBL16897945 | 0.78 | NPC1 (0.51) | NPC1RAB9AMAPK1KDM1AMAOA | |
| SCHEMBL16897870 | 0.78 | NPC1 (0.51) | NPC1RAB9AMAPK1KDM1AMAOA | |
| SCHEMBL2295519 | 0.78 | CHRM4 (0.47) | CHRM4MAPK1ALOX5FDFT1TP53 | |
| SCHEMBL3272030 | 0.78 | CHRM4 (0.43) | CHRM4NPC1RAB9AMAPK1ALOX5 | |
| SCHEMBL2295049 | 0.78 | CHRM4 (0.47) | CHRM4MAPK1ALOX5FDFT1TP53 | |
| SCHEMBL2297996 | 0.78 | CHRM4 (0.47) | CHRM4MAPK1ALOX5FDFT1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6274735-B1 | RENIN INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |