Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | TTK | P33981 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453666 | 0.81 | MAPT (0.45) | AURKATTKAURKBINCENPPIK3CA | |
| SCHEMBL16017538 | 0.79 | PIK3CA (0.50) | AURKATTKAURKBINCENPPIK3CA | |
| SCHEMBL460240 | 0.79 | AURKA (0.55) | AURKATTKAURKBINCENPMAPT | |
| SCHEMBL2684595 | 0.76 | AURKA (1.00) | AURKATTKAURKBINCENPPIK3CA | |
| SCHEMBL452518 | 0.74 | PIK3CA (0.59) | PIK3CA | |
| SCHEMBL16020296 | 0.73 | DYRK1A (0.50) | PIK3CAMKNK1MKNK2FYN | |
| SCHEMBL453667 | 0.70 | MAPT (0.43) | AURKATTKAURKBINCENPPIK3CA | |
| SCHEMBL532633 | 0.68 | PIK3CA (0.74) | PIK3CAFYNHSD17B10DCTPP1 | |
| SCHEMBL27794762 | 0.67 | MAPT (0.64) | PIK3CAMKNK1MKNK2MAPTFYN | |
| SCHEMBL2979751 | 0.66 | FYN (0.50) | MKNK1MKNK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121317-A9 | IMIDAZOTHIADIAZOLES FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2012-03-15 | — | — | WO | disclosed |
| WO-2011121317-A1 | IMIDAZO [2,1-B] [1,3,4] THIADIAZOLES AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-10-06 | — | — | WO | disclosed |